Revisit the whole picture.
Frequent flares, persistent symptoms, or urate deposits under the skin can be reasons to reassess a treatment plan. A clinician may review the diagnosis, previous medicines, dose and tolerance, urate results, and other health conditions.
Consider the right next option.
For some patients, the next step may be adjusting urate-lowering treatment or arranging a specialist evaluation. Treatment choices depend on clinical findings, prior treatment, and individual risks.
Where infusion treatment fits.
For selected people with severe gout that remains uncontrolled despite other treatments, specialists may consider pegloticase infusions. It is not a treatment for every person with gout.
Pegloticase requires screening and ongoing monitoring, including blood tests and observation for infusion reactions. Serious allergic reactions can occur. A treating clinician must determine whether it is appropriate and where treatment can be safely provided.
Learn more: ACR patient guide to pegloticase and NIAMS gout treatment guide.